FOLFOX chemotherapy regimen
The FOLFOX regimen includes 5-fluorouracil (5-FU), oxaliplatin and folinic acid. It is used in the treatment of colorectal carcinoma. Which drugs in regimen is causal in yet unclear
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The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
I - Interstitial/parenchymal lung disease
I.a
Pneumonitis (interstitial lung disease/ILD)
I.b
Pneumonitis (ILD), acute and/or severe (may cause ARDS)
I.c
Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
I.e
Organizing pneumonia pattern (an area or areas of consolidation on imaging)
I.g
Pulmonary fibrosis
I.w
Abnormal lung function/pulmonary physiology (PFTs) without necessarily imaging or clinical evidence
I.x
Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)
I.z
Progression, acceleration or exacerbation of preexisting ILD/fibrosis
I.bd
Fatal pulmonary fibrosis