The Drug-Induced Respiratory Disease Website and App

Angiotensin II receptor blockers (ARB) - Sartans

Novel ARB blockers may induce similar class-related adverse events. In some patients, cough or angioedema from ACE inhibitors may also occur with subsequent exposure to ARB. Caution is advised

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV - Airway involvement

IV.ab

Cough (lone)

V - Central-large-upper airway (incl. pharyngeal-nasal) involvement

V.a

Angioedema (may cause UAO, asphyxia and death)

X - Systemic/Distant conditions, syndromes and reactions

X.aw

Visceral angioedema (can cause relapsing abdominal pain)