The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Angioedema (may cause UAO, asphyxia and death)
In a sizable fraction of patients who develop angioedema while on ARBs, a history of previous episodes with ACEI is elicited. Icatibant may be as beneficial in this indication as it is in ACEI-induced angioedema (PMID 25646708)
Publications
Disposition of emergency department patients presenting with angiotensin-converting enzyme inhibitor-induced angioedema.
International journal of emergency medicine 2025 Jan 10;18;11 — 2025 Jan 10 — 11
Angiotensin-Converting Enzyme Inhibitors and Other Medications Associated With Angioedema.
Cureus 2023 Nov;15;e49306 — 2023 Nov — e49306
Clinical experiences and case review of angiotensin II receptor blocker-related angioedema in Korea.
Basic & clinical pharmacology & toxicology 2019 Jan;124;115-122 — 2019 Jan — 115-122
Treatment of angiotensin receptor blocker-induced angioedema: A case series.
The Laryngoscope 2015 Jul;125;1619-23 — 2015 Jul — 1619-23
Drug-induced visceral angioedema.
Journal of community hospital internal medicine perspectives 2014;4; — 2014
Lump in the throat - a case study.
Australian family physician 2013 Dec;42;863-6 — 2013 Dec — 863-6
Severe angioedema induced by angiotensin II receptor blocker.
International journal of cardiology 2013 Sep 20;168;e15-6 — 2013 Sep 20 — e15-6
Side effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists: are we facing a new syndrome.
The American journal of cardiology 2012 Nov 15;110;1552-3 — 2012 Nov 15 — 1552-3
The role of angiotensin receptor blockers in patients with angiotensin-converting enzyme inhibitor-induced angioedema.
The Annals of pharmacotherapy 2011 Apr;45;520-4 — 2011 Apr — 520-4
[Angioedema due to losartan].
Medicina clinica 2011 Sep 10;137;281-2 — 2011 Sep 10 — 281-2
Risk of angioedema with angiotensin receptor blockers in patients with prior angioedema associated with angiotensin-converting enzyme inhibitors: a meta-analysis.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2008 Nov;101;495-9 — 2008 Nov — 495-9
Angiotensin-converting enzyme inhibitor (ACE-I)- and angiotensin receptor blocker (ARB)-related angioedema: a neglected issue in daily practice in Greece.
The European journal of general practice 2007;13;239-41 — 2007 — 239-41
Can angiotensin II receptor blockers be used in patients who have developed a cough or angioedema as a result of taking an ACE inhibitor?
Cleveland Clinic journal of medicine 2001 Mar;68;189-90 — 2001 Mar — 189-90
Angiotensin II receptor blockers in patients with ACE inhibitor-induced angioedema.
The Annals of pharmacotherapy 2000 Apr;34;526-8 — 2000 Apr — 526-8
Ultrasonic parameters of bone in young normals: effect of age and sex.
European journal of clinical investigation 1996 Nov;26 — 1996 Nov — 947-50