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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.a

Angioedema (may cause UAO, asphyxia and death)

In a sizable fraction of patients who develop angioedema while on ARBs, a history of previous episodes with ACEI is elicited. Icatibant may be as beneficial in this indication as it is in ACEI-induced angioedema (PMID 25646708)

Publications

Briggs B, Cline D, Husain I

Disposition of emergency department patients presenting with angiotensin-converting enzyme inhibitor-induced angioedema.

International journal of emergency medicine. 2025;18(1):11

Landry L, Witten T, Anwar AI, Jackson CN, Talbot NC, Ahmadzadeh S, Varrassi G, Shekoohi S, Kaye AD

Angiotensin-Converting Enzyme Inhibitors and Other Medications Associated With Angioedema.

Cureus. 2023;15(11):e49306

Kim H, Baik SY, Yang SJ, Kim TM, Lee SH, Cho JH, Choi IY, Kim JH, Yoon KH, Kim HS

Clinical experiences and case review of angiotensin II receptor blocker-related angioedema in Korea.

Basic & clinical pharmacology & toxicology. 2019;124(1):115-122

Strassen U, Bas M, Hoffmann TK, Knopf A, Greve J

Treatment of angiotensin receptor blocker-induced angioedema: A case series.

The Laryngoscope. 2015;125(7):1619-23

Thalanayar PM, Ghobrial I, Lubin F, Karnik R, Bhasin R

Drug-induced visceral angioedema.

Journal of community hospital internal medicine perspectives. 2014;4(4)

Gabb G, Andrew N

Lump in the throat - a case study.

Australian family physician. 2013;42(12):863-6

Hamasaki H, Hiraishi C, Yanai H

Severe angioedema induced by angiotensin II receptor blocker.

International journal of cardiology. 2013;168(1):e15-6

Montoro de Francisco A, García-Luque A, Fernández M, Puerro M

Side effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists: are we facing a new syndrome.

The American journal of cardiology. 2012;110(10):1552-3

Beavers CJ, Dunn SP, Macaulay TE

The role of angiotensin receptor blockers in patients with angiotensin-converting enzyme inhibitor-induced angioedema.

The Annals of pharmacotherapy. 2011;45(4):520-4

Orgaz-Molina J, Soriano-Hernández MI, Husein-Elahmed H, Arias-Santiago S

[Angioedema due to losartan].

Medicina clinica. 2011;137(6):281-2

Haymore BR, Yoon J, Mikita CP, Klote MM, DeZee KJ

Risk of angioedema with angiotensin receptor blockers in patients with prior angioedema associated with angiotensin-converting enzyme inhibitors: a meta-analysis.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2008;101(5):495-9

Symvoulakis EK, Kyrmizakis DE, Drivas EI, Bizakis J, Velegrakis GA, Lionis C

Angiotensin-converting enzyme inhibitor (ACE-I)- and angiotensin receptor blocker (ARB)-related angioedema: a neglected issue in daily practice in Greece.

The European journal of general practice. 2007;13(4):239-41

Vidt DG

Can angiotensin II receptor blockers be used in patients who have developed a cough or angioedema as a result of taking an ACE inhibitor?

Cleveland Clinic journal of medicine. 2001;68(3):189-90

Warner KK, Visconti JA, Tschampel MM

Angiotensin II receptor blockers in patients with ACE inhibitor-induced angioedema.

The Annals of pharmacotherapy. 2000;34(4):526-8

Minnisola S, Tirafili C, Rosso R, Costa G, Mazzouli G

Ultrasonic parameters of bone in young normals: effect of age and sex.

European journal of clinical investigation. 1996;26(11):947-50