Like NO, molecular oxygen or dioxygen or O2 is listed as a drug. Oxygen can cause lung damage known as hyperoxic lung injury (HLI/HOLI). Oxygen can also trigger or potentiate amiodarone-, chemotherapy- and radiation-induced lung injury. Elevated FIO2 above 0.6 for >24hr may cause HLI/HOLI. See PMID: 21994818, 22804568, 23271823. See also PMID 4936578, 4948324, 6247652, 9887137, 15485081, 20430708, 25314313. And an interesting study in pigs at PMID 10924582
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
