The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Publications

Aggarwal NR, Brower RG

Targeting normoxemia in acute respiratory distress syndrome may cause worse short-term outcomes because of oxygen toxicity.

Annals of the American Thoracic Society. 2014;11(9):1449-53

Thomson L, Paton J

Oxygen toxicity.

Paediatric respiratory reviews. 2014;15(2):120-3

Louge P, Cantais E, Palmier B

[Acute respiratory distress syndrome after prolonged hyperbaric oxygen therapy: a case of pulmonary oxygen toxicity?].

Annales francaises d'anesthesie et de reanimation. 2001;20(6):559-62

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Case records of the Massachusetts General Hospital. Case 7-1967.

The New England journal of medicine. 1967;276(7):401-11

Nash G, Blennerhassett JB, Pontoppidan H

Pulmonary lesions associated with oxygen therapy and artificial ventilation.

The New England journal of medicine. 1967;276(7):368-74

Kapanci Y, Tosco R, Eggermann J, Gould VE

Oxygen pneumonitis in man., Light- and electron-microscopic morphometric studies.

Chest. 1972;62(2):162-9

Clark JM, Lambertsen CJ

Pulmonary oxygen toxicity: a review.

Pharmacological reviews. 1971;23(2):37-133

Barber RE, Hamilton WK

Oxygen toxicity in man. A prospective study in patients with irreversible brain damage.

The New England journal of medicine. 1970;283(27):1478-84

Jackson RM

Pulmonary oxygen toxicity.

Chest. 1985;88(6):900-5

Ingrassia TS 3rd, Ryu JH, Trastek VF, Rosenow EC 3rd

Oxygen-exacerbated bleomycin pulmonary toxicity.

Mayo Clinic proceedings. 1991;66(2):173-8

Saussine M, Colson P, Alauzen M, Mary H

Postoperative acute respiratory distress syndrome. A complication of amiodarone associated with 100 percent oxygen ventilation.

Chest. 1992;102(3):980-1