The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Respiratory acidosis - Hypercapnia
Publications
Oxygen-induced hypercapnia in COPD: myths and facts.
Critical care (London, England) 2012 Oct 29;16;323 — 2012 Oct 29 — 323
Unrecognized severe postoperative hypercapnia: a case of apneic oxygenation.
Mayo Clinic proceedings 1998 Jan;73;51-4 — 1998 Jan — 51-4
Severe hypercapnia after low-flow oxygen therapy in patients with neuromuscular disease and diaphragmatic dysfunction.
Mayo Clinic proceedings 1995 Apr;70;327-30 — 1995 Apr — 327-30