The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.m

Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

Publications

Thomson L, Paton J

Oxygen toxicity.

Paediatric respiratory reviews 2014 Jun;15;120-3 — 2014 Jun — 120-3

Bhandari V

Hyperoxia-derived lung damage in preterm infants.

Seminars in fetal & neonatal medicine 2010 Aug;15;223-9 — 2010 Aug — 223-9

Nash G, Blennerhassett JB, Pontoppidan H

Pulmonary lesions associated with oxygen therapy and artifical ventilation.

The New England journal of medicine 1967 Feb 16;276;368-74 — 1967 Feb 16 — 368-74

Kapanci Y, Tosco R, Eggermann J, Gould VE

Oxygen pneumonitis in man., Light- and electron-microscopic morphometric studies.

Chest 1972 Aug;62;162-9 — 1972 Aug — 162-9