The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: Diffuse alveolar damage (DAD-pattern) (see also IL)
Publications
Diffuse alveolar damage in a young cat.
The Journal of veterinary medical science. 2011;73(10):1347-9
Case records of the Massachusetts General Hospital. Case 7-1967.
The New England journal of medicine. 1967;276(7):401-11
Pulmonary hyaline membrane: sites of formation in adult lungs after assisted respiration and inhalation of oxygen.
The Journal of pathology and bacteriology. 1968;95(2):481-8
Postoperative acute respiratory distress syndrome. A complication of amiodarone associated with 100 percent oxygen ventilation.
Chest. 1992;102(3):980-1
Diffuse alveolar damage--the role of oxygen, shock, and related factors. A review.
The American journal of pathology. 1976;85(1):209-28