Pneumotox » Drug » Biologics

Biologics

Under construction. Targeted and nontargeted drugs can produce a vast array of respiratory adverse effects. Here, review articles are cited. Refer to specific drugs. Glossary at PMID 24377743

Last update : 14/05/2014

X.b Antiphospholipid antibodies w/wo the APL syndrome

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

XVII.a Respiratory tract infection incl. pneumonia

XVII.b Opportunistic pulmonary/systemic infections

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

More detailed checklist

The Drug-Induced Respiratory Disease Website