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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Balsalazide
1
A prodrug of/for mesalazine
Last update :
21/01/2019
I - Interstitial/parenchymal lung disease
I.c
Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
1
I.d
Organizing pneumonia pattern (an area or areas of consolidation on imaging)
1
V - Pleural and/or pericardial involvement
V.m
Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
1
XV - Pathology
XV.b
Path: Eosinophilic pneumonia (subacute or acute) (see also Ic)
1
XV.c
Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)
1
XV.ac
Path: Pulmonary vasculitis other than capillaritis
-
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Mesalazine-Mesalamine-5-aminosalicylic acid-5-ASA