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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Antithymocyte globulin (ATG-ALG) - Antithymocyte immunoglobulin (ATI)
3
Last update :
25/02/2016
I - Interstitial/parenchymal lung disease
I.g
Pulmonary fibrosis
1
II - Pulmonary edema - Acute lung injury - ARDS
II.a
Pulmonary edema, noncardiogenic (NCPE)
2
II.b
ARDS - Acute lung injury
2
II.j
Transient pulmonary opacities/infiltrates (see also under Iav)
1
X - Systemic/Distant conditions, syndromes and reactions
X.f
Anaphylaxis-Anaphylactoid reaction (can be fatal)
2
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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