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Antiplatelet agents: Glycoprotein IIb/IIIa inhibitors

These drugs may increase the risk of intra- and postprocedural bleeding in patients who undergo various minimally-invasive biopsy procedures (See under 'hemoptysis' and PMID 23617483)

Last update : 10/10/2016

II.e Transfusion-related acute lung injury (TRALI) (May cause ARDS)

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

III.c Hemoptysis

VIII.q Tongue involvement (edema, glossitis, hematoma)

IX.x Thoracic epidural or spinal hematoma

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

More detailed checklist

The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.