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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Interferon gamma
1
IFN gamma,INF gamma,IFN-gamma,INF-gamma
Last update :
20/01/2012
I - Interstitial/parenchymal lung disease
I.l
Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)
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I.w
Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)
1
I.y
Progression, acceleration or exacerbation of preexisting ILD/fibrosis
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VII - Mediastinal involvement
VII.f
An enlarged or dense thymus
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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