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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Pomalidomide
1
Last update :
09/09/2012
I - Interstitial/parenchymal lung disease
I.a
Pneumonitis (ILD), acute and/or severe (may cause ARDS)
1
I.b
Pneumonitis (ILD)
1
I.c
Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
1
I.g
Pulmonary fibrosis
1
XVII - Infections & related conditions
XVII.a
Respiratory tract infection incl. pneumonia
1
XIX - Cytological, biochemical features of/in BAL, pleural fluid or FNA
XIX.c
BAL: An excess proportion of eosinophils
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Lenalidomide
Thalidomide