Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website and App

Pacemaker leads - Implantable cardiac devices

Including but not limited to implantable defibrillators. Complications may develop with insertion or later

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLV - Pleural and/or pericardial involvement

XLVI - Pulmonary vasculopathy

XLVII - Mediastinal involvement

XLVIII - Neuromuscular / CNS involvement - Disordered breathing (during sleep)

L - Miscellaneous

LI - Cardiovascular involvement / toxicity