The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Mackenzie M, Wood LA

Lingual angioedema associated with everolimus.

Acta oncologica (Stockholm, Sweden) 2010;49;107-9 — 2010 — 107-9

Duerr M, Glander P, Diekmann F, Dragun D, Neumayer HH, Budde K

Increased incidence of angioedema with ACE inhibitors in combination with mTOR inhibitors in kidney transplant recipients.

Clinical journal of the American Society of Nephrology : CJASN 2010 Apr;5;703-8 — 2010 Apr — 703-8

Fuchs U, Zittermann A, Berthold HK, Tenderich G, Deyerling KW, Minami K, Koerfer R

Immunosuppressive therapy with everolimus can be associated with potentially life-threatening lingual angioedema.

Transplantation 2005 Apr 27;79;981-3 — 2005 Apr 27 — 981-3