The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Junpaparp P, Sharma B, Samiappan A, Rhee JH, Young KR

Everolimus-induced severe pulmonary toxicity with diffuse alveolar hemorrhage.

Annals of the American Thoracic Society 2013 Dec;10;727-9 — 2013 Dec — 727-9

Kirby S, Satoskar A, Brodsky S, Pope-Harman A, Nunley D, Hitchcock C, Pelletier R, Ross P, Nadasdy T, Shilo K

Histological spectrum of pulmonary manifestations in kidney transplant recipients on sirolimus inclusive immunosuppressive regimens.

Diagnostic pathology 2012 Mar 14;7;25 — 2012 Mar 14 — 25

Depuydt P, Nollet J, Benoit D, Praet M, Caes F

Fatal acute pulmonary injury associated with everolimus.

The Annals of pharmacotherapy 2012 Mar;46;e7 — 2012 Mar — e7

Das S, Cherian SV, Das N, Garcha AS, Lenox R, Sexton J

Persistent dyspnea in a 59-year-old woman receiving immunosuppressants.

Chest 2011 Sep;140;818-822 — 2011 Sep — 818-822

White DA, Camus P, Endo M, Escudier B, Calvo E, Akaza H, Uemura H, Kpamegan E, Kay A, Robson M, Ravaud A, Motzer RJ

Noninfectious pneumonitis after everolimus therapy for advanced renal cell carcinoma.

American journal of respiratory and critical care medicine 2010 Aug 01;182;396-403 — 2010 Aug 01 — 396-403

Vandewiele B, Vandecasteele SJ, Vanwalleghem L, De Vriese AS

Diffuse alveolar hemorrhage induced by everolimus.

Chest 2010 Feb;137;456-9 — 2010 Feb — 456-9

Patel AV, Hahn T, Bogner PN, Loud PA, Brown K, Paplham P, Syta M, Battiwalla M, McCarthy PL

Fatal diffuse alveolar hemorrhage associated with sirolimus after allogeneic hematopoietic cell transplantation.

Bone marrow transplantation 2010 Aug;45;1363-4 — 2010 Aug — 1363-4

Rabe C, Appenrodt B, Hoff C, Ewig S, Klehr HU, Sauerbruch T, Nickenig G, Tasci S

Severe respiratory failure due to diffuse alveolar hemorrhage: clinical characteristics and outcome of intensive care.

Journal of critical care 2010 Jun;25;230-5 — 2010 Jun — 230-5

Khalife WI, Kogoj P, Kar B

Sirolimus-induced alveolar hemorrhage.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2007 Jun;26;652-7 — 2007 Jun — 652-7