The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Junpaparp P, Sharma B, Samiappan A, Rhee JH, Young KR

Everolimus-induced severe pulmonary toxicity with diffuse alveolar hemorrhage.

Annals of the American Thoracic Society. 2013;10(6):727-9

Kirby S, Satoskar A, Brodsky S, Pope-Harman A, Nunley D, Hitchcock C, Pelletier R, Ross P, Nadasdy T, Shilo K

Histological spectrum of pulmonary manifestations in kidney transplant recipients on sirolimus inclusive immunosuppressive regimens.

Diagnostic pathology. 2012;7:25

Depuydt P, Nollet J, Benoit D, Praet M, Caes F

Fatal acute pulmonary injury associated with everolimus.

The Annals of pharmacotherapy. 2012;46(3):e7

Das S, Cherian SV, Das N, Garcha AS, Lenox R, Sexton J

Persistent dyspnea in a 59-year-old woman receiving immunosuppressants.

Chest. 2011;140(3):818-822

White DA, Camus P, Endo M, Escudier B, Calvo E, Akaza H, Uemura H, Kpamegan E, Kay A, Robson M, Ravaud A, Motzer RJ

Noninfectious pneumonitis after everolimus therapy for advanced renal cell carcinoma.

American journal of respiratory and critical care medicine. 2010;182(3):396-403

Vandewiele B, Vandecasteele SJ, Vanwalleghem L, De Vriese AS

Diffuse alveolar hemorrhage induced by everolimus.

Chest. 2010;137(2):456-9

Patel AV, Hahn T, Bogner PN, Loud PA, Brown K, Paplham P, Syta M, Battiwalla M, McCarthy PL

Fatal diffuse alveolar hemorrhage associated with sirolimus after allogeneic hematopoietic cell transplantation.

Bone marrow transplantation. 2010;45(8):1363-4

Rabe C, Appenrodt B, Hoff C, Ewig S, Klehr HU, Sauerbruch T, Nickenig G, Tasci S

Severe respiratory failure due to diffuse alveolar hemorrhage: clinical characteristics and outcome of intensive care.

Journal of critical care. 2010;25(2):230-5

Khalife WI, Kogoj P, Kar B

Sirolimus-induced alveolar hemorrhage.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2007;26(6):652-7