The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Organizing pneumonia pattern (an area or areas of consolidation on imaging)
Publications
Kirby S, Satoskar A, Brodsky S, Pope-Harman A, Nunley D, Hitchcock C, Pelletier R, Ross P, Nadasdy T, Shilo K
Histological spectrum of pulmonary manifestations in kidney transplant recipients on sirolimus inclusive immunosuppressive regimens.
Diagnostic pathology 2012 Mar 14;7;25 — 2012 Mar 14 — 25
An unusual presentation of sirolimus associated cough in a renal transplant recipient.
Transplantation proceedings 2007 Dec;39;3463-4 — 2007 Dec — 3463-4
Bauer C, Lidove O, Lamotte C, Petit T, Lieberherr D, Chauveheid MP, Legendre C, Crestani B, Dombret MC, Laissy JP, Antoine C, Pegaz-Fiornet B, Papo T
[Sirolimus-associated interstitial pneumonitis in a renal transplant patient].
La Revue de medecine interne 2006 Mar;27;248-52 — 2006 Mar — 248-52