Pneumotox » Pattern » VI.a - Pulmonary embolism - Venous thrombosis/thromboembolism

VI.a

Pulmonary embolism - Venous thrombosis/thromboembolism

Acute/chronic. Due to the high background incidence rate of naturally-occurring VTE, a cause-and-effect relationship with drugs or procedures may be difficult to establish firmly. Epidemiologic studies can be supportive (PMID 25924683). A search for antiphospholipid antibodies is indicated. Chronic iatrogenic thromboembolism, for instance in patients with cardiac wires and leads may cause thromboembolic pulmonary hypertension (PMID 24881082)

Last update : 01/01/1970

Causative drugs

82

Testosterone

VI.a

2

Thalidomide

I.a I.b I.c I.d II.b VI.a VI.b XV.c XV.e XIX.a XIX.b

2

Thrombin

VI.a

1

Tranexamic acid

VI.a

1

Transcatheter embolization

VI.a

2

Transhepatic arterial chemoembolization (TACE)

I.b I.c I.d I.e I.y I.z II.b V.a VI.a VI.e VI.v VI.aa XI.aa XV.c XVI.s XVIII.h

2

Venous cannula, catheter, lead(s), implantable device

VI.a VI.r

5

1
2
3
4

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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