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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Thalidomide

2

VI.a Pulmonary embolism - Venous thrombosis/thromboembolism

2
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Lenalidomide
2
Pomalidomide
1

Publications

Frequency of thromboembolic events associated with thalidomide in the non-cancer setting: a case report and review of the literature.
Journal of drugs in dermatology : JDD 2009 Aug;8;765-9 2009 Aug
Pulmonary embolism in a patient with multiple myeloma receiving thalidomide-dexamethasone therapy.
International journal of hematology 2008 Jun;87;542-544 2008 Jun
Thalidomide- and lenalidomide-associated thromboembolism among patients with cancer.
JAMA 2006 Dec 06;296;2558-60 2006 Dec 06
Thalidomide therapy and deep venous thrombosis in multiple myeloma.
Mayo Clinic proceedings 2005 Dec;80;1549-51 2005 Dec
Thromboembolic events in patients with myelodysplastic syndrome receiving thalidomide in combination with darbepoietin-alpha.
British journal of haematology 2003 Apr;121;101-3 2003 Apr
A high rate of venous thromboembolism in a multi-institutional phase II trial of weekly intravenous gemcitabine with continuous infusion fluorouracil and daily thalidomide in patients with metastatic renal cell carcinoma.
Cancer 2002 Oct 15;95;1629-36 2002 Oct 15

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