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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Excipients, erroneously/deliberately administered i.v.
5
Review at PMID 25341165
Last update :
21/02/2022
VI - Pulmonary vasculopathies
VI.b
Pulmonary arterial hypertension
2
VI.e
Fat/oil embolism - The FES embolism syndrome
2
VI.g
Foreign body pulmonary vasculopathy (Excipient lung disease)
3
XV - Pathology
XV.ag
Path: Foreign body embolism, microangiopathy, vasculopathy
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
Crospovidone
Excipients-Vehicle-Preservatives (of drugs)
Oil-/lipid-based formulations (parenteral)
Talc (inhaled, sniffed, i.v., intrapleural)