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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Crospovidone
2
A drug excipient
Last update :
30/08/2012
VI - Pulmonary vasculopathies
VI.g
Foreign body pulmonary vasculopathy (Excipient lung disease)
2
XV - Pathology
XV.q
Path: Foreign body deposits/granulomatous reaction
1
XV.ag
Path: Foreign body embolism, microangiopathy, vasculopathy
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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