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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Excipients, erroneously/deliberately administered i.v.

5

VI.g Foreign body pulmonary vasculopathy (Excipient lung disease)

3

See PMID 34510050

Last update : 16/09/2021
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
5
Crospovidone
2
Excipients-Vehicle-Preservatives (of drugs)
5
Oil-/lipid-based formulations (parenteral)
3
Talc (inhaled, sniffed, i.v., intrapleural)
3

Publications

Fatal Excipients: An Autopsy Case Series of Excipient Lung Disease.
The American journal of forensic medicine and pathology 2022 Mar 01;43;81-89 2022 Mar 01
Excipient-Induced Pulmonary Vascular Disease: An Underrecognized and Deadly Complication of Opioid Addiction.
Lung 2021 Aug;199;363-368 2021 Aug
Dyspnea and Pulmonary Hypertension with Diffuse Centrilobular Nodules.
Annals of the American Thoracic Society 2016 Oct;13;1858-1860 2016 Oct

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