The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Publications

Abel ML, Kokosis G, Blazer DG

Pulmonary toxicity after intraperitoneal mitomycin C: a case report of a rare complication of HIPEC.

World journal of surgical oncology. 2017;15(1):49

Wada H, Nakano Y, Yamada H, Saiga T, Yamanaka A, Sakai N

Intravesical mitomycin-C-induced interstitial pneumonia.

Respiration; international review of thoracic diseases. 2010;80(3):256-9

Okuno SH, Frytak S

Mitomycin lung toxicity. Acute and chronic phases.

American journal of clinical oncology. 1997;20(3):282-4

Buzdar AU, Legha SS, Luna MA, Tashima CK, Hortobagyi GN, Blumenschein GR

Pulmonary toxicity of mitomycin.

Cancer. 1980;45(2):236-44

Doyle LA, Ihde DC, Carney DN, Bunn PA, Cohen MH, Matthews MJ, Puffenbarger R, Cordes RS, Minna JD

Combination chemotherapy with doxorubicin and mitomycin C in non-small cell bronchogenic carcinoma. Severe pulmonary toxicity from q 3 weekly mitomycin C.

American journal of clinical oncology. 1984;7(6):719-24

Rao SX, Ramaswamy G, Levin M, McCravey JW

Fatal acute respiratory failure after vinblastine-mitomycin therapy in lung carcinoma.

Archives of internal medicine. 1985;145(10):1905-7

Sheldon R, Slaughter D

A syndrome of microangiopathic hemolytic anemia, renal impairment, and pulmonary edema in chemotherapy-treated patients with adenocarcinoma.

Cancer. 1986;58(7):1428-36

Krauss S, Sonoda T, Solomon A

Treatment of advanced gastrointestinal cancer with 5-fluorouracil and mitomycin C.

Cancer. 1979;43(5):1598-603