The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVI.b

Pulmonary arterial hypertension

Publications

Certain MC, Chaumais MC, Jaïs X, Savale L, Seferian A, Parent F, Georges M, Favrolt N, Bourdin A, Boissin C, Cottin V, Traclet J, Renard S, Noel V, Picard F, Girerd B, Ghigna MR, Perros F, Sitbon O, Bonniaud P, Humbert M, Montani D

Characteristics and Long-term Outcomes of Pulmonary Venoocclusive Disease Induced by Mitomycin C.

Chest 2021 03;159;1197-1207 — 2021 03 — 1197-1207

Botros L, Van Nieuw Amerongen GP, Vonk Noordegraaf A, Bogaard HJ

Recovery from mitomycin-induced pulmonary arterial hypertension.

Annals of the American Thoracic Society 2014 Mar;11;468-70 — 2014 Mar — 468-70

McCarthy JT, Staats BA

Pulmonary hypertension, hemolytic anemia, and renal failure. A mitomycin-associated syndrome.

Chest 1986 Apr;89;608-11 — 1986 Apr — 608-11