The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Castro M, Veeder MH, Mailliard JA, Tazelaar HD, Jett JR

A prospective study of pulmonary function in patients receiving mitomycin.

Chest 1996 Apr;109;939-44 — 1996 Apr — 939-44

Buzdar AU, Legha SS, Luna MA, Tashima CK, Hortobagyi GN, Blumenschein GR

Pulmonary toxicity of mitomycin.

Cancer 1980 Jan 15;45;236-44 — 1980 Jan 15 — 236-44

Luedke D, McLaughlin TT, Daughaday C, Luedke S, Harrison B, Reed G, Martello O

Mitomycin C and vindesine associated pulmonary toxicity with variable clinical expression.

Cancer 1985 Feb 01;55;542-5 — 1985 Feb 01 — 542-5

Chang AY, Kuebler JP, Pandya KJ, Israel RH, Marshall BC, Tormey DC

Pulmonary toxicity induced by mitomycin C is highly responsive to glucocorticoids.

Cancer 1986 Jun 15;57;2285-90 — 1986 Jun 15 — 2285-90