The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.g

Pulmonary fibrosis

The fibrosis caused by nitrosoureas has the reputation for being severe, progressive and fatal

Publications

Skorupski KA, Durham AC, Duda L, Sørenmo KU

Pulmonary fibrosis after high cumulative dose nitrosourea chemotherapy in a cat.

Veterinary and comparative oncology 2008 Jun;6;120-5 — 2008 Jun — 120-5

Stuart MJ, Chao NS, Horning SJ, Wong RM, Negrin RS, Johnston LJ, Shizuru JA, Long GD, Blume KG, Stockerl-Goldstein KE

Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2001;7;552-60 — 2001 — 552-60

Dent RG

Fatal pulmonary toxic effects of lomustine.

Thorax 1982 Aug;37;627-9 — 1982 Aug — 627-9

Cordonnier C, Vernant JP, Mital P, Lange F, Bernaudin JF, Rochant H

Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.

Cancer 1983 May 15;51;1814-8 — 1983 May 15 — 1814-8

Weiss RB, Poster DS, Penta JS

The nitrosoureas and pulmonary toxicity.

Cancer treatment reviews 1981 Jun;8;111-25 — 1981 Jun — 111-25

Smith AC

The pulmonary toxicity of nitrosoureas.

Pharmacology & therapeutics 1989;41;443-60 — 1989 — 443-60

Massin F, Coudert B, Foucher P, Lombard JN, Reybet-Degat O, Jeannin L, Camus P

[Nitrosourea-induced lung diseases].

Revue des maladies respiratoires 1992;9;575-82 — 1992 — 575-82

Hoogstraten B, Haas CD, Haut A, Talley RW, Rivkin S, Isaacs BL

CCNU and bleomycin in the treatment of cancer: a Southwest Oncology Group Study.

Medical and pediatric oncology 1975;1;95-106 — 1975 — 95-106