The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)

Publications

Stuart MJ, Chao NS, Horning SJ, Wong RM, Negrin RS, Johnston LJ, Shizuru JA, Long GD, Blume KG, Stockerl-Goldstein KE

Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2001;7(10):552-60

Weiss RB, Poster DS, Penta JS

The nitrosoureas and pulmonary toxicity.

Cancer treatment reviews. 1981;8(2):111-25

Smith AC

The pulmonary toxicity of nitrosoureas.

Pharmacology & therapeutics. 1989;41(3):443-60

Massin F, Coudert B, Foucher P, Lombard JN, Reybet-Degat O, Jeannin L, Camus P

[Nitrosourea-induced lung diseases].

Revue des maladies respiratoires. 1992;9(6):575-82