The Drug-Induced Respiratory Disease Website and App

Aminorex

This anorectic drug was recalled in the 1960s, following an epidemic of pulmonary hypertension in young ladies (PMID 21531521, 21764154). The antihelminthic levamisole is currently (2013) found in most street cocaine samples. this adulterant is biotransformed into aminorex by mammals. Vigilance is warranted. (See under levamisole and at PMID 23436169 & 21764154

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VII - Pulmonary vasculopathy

VII.b

Pulmonary arterial hypertension

XIX - Pathology

XIX.ax

Path: Pulmonary hypertension incl. angiomatoid vasculopathy