The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVI.b

Pulmonary arterial hypertension

Publications

Karch SB, Defraia B, Messerini L, Mari F, Vaiano F, Bertol E

Aminorex associated with possible idiopathic pulmonary hypertension in a cocaine user.

Forensic science international 2014 Jul;240;e7-10 — 2014 Jul — e7-10

Karch SB, Mari F, Bartolini V, Bertol E

Aminorex poisoning in cocaine abusers.

International journal of cardiology 2012 Jul 26;158;344-6 — 2012 Jul 26 — 344-6

Gaine SP, Rubin LJ, Kmetzo JJ, Palevsky HI, Traill TA

Recreational use of aminorex and pulmonary hypertension.

Chest 2000 Nov;118;1496-7 — 2000 Nov — 1496-7

Kramer MS, Lane DA

Aminorex, dexfenfluramine, and primary pulmonary hypertension.

Journal of clinical epidemiology 1998 Apr;51;361-4 — 1998 Apr — 361-4

Brenot F, Herve P, Petitpretz P, Parent F, Duroux P, Simonneau G

Primary pulmonary hypertension and fenfluramine use.

British heart journal 1993 Dec;70;537-41 — 1993 Dec — 537-41

Follath F, Burkart F, Schweizer W

Drug-induced pulmonary hypertension?

British medical journal 1971 Jan 30;1;265-6 — 1971 Jan 30 — 265-6

Kay JM, Smith P, Heath D

Aminorex and the pulmonary circulation.

Thorax 1971 May;26;262-70 — 1971 May — 262-70

Berthou JD, Delahaye JP, Brune J, Dorsit G, Delaye J, Roques JC, Gonin A

[Apparently primary pulmonary arterial hypertension in a woman who had taken appetite depressants (Aminorex)].

Revue de tuberculose et de pneumologie 1972 Sep-Oct;36;944-51 — 1972 Sep-Oct — 944-51

Loogen F, Worth H, Schwan G, Goeckenjan G, Lösse B, Horstkotte D

Long-term follow-up of pulmonary hypertension in patients with and without anorectic drug intake.

Cor et vasa 1985;27;111-24 — 1985 — 111-24

Gurtner HP

[Chronic pulmonary hypertension of vascular etiology, plexogenic pulmonary arteriopathy and the appetite depressant Aminorex: lessons from an epidemic].

Schweizerische medizinische Wochenschrift 1985 Jun 15;115;818-27 — 1985 Jun 15 — 818-27

Gurtner HP

Aminorex and pulmonary hypertension. A review.

Cor et vasa 1985;27;160-71 — 1985 — 160-71

Widgren S

Pulmonary hypertension related to aminorex intake. Histologic, ultrastructural, and morphometric studies of 37 cases in Switzerland.

Current topics in pathology. Ergebnisse der Pathologie 1977;64;1-64 — 1977 — 1-64

Simon H, Felix R

[Reversible pulmonary arterial hypertension after medication of aminorexfumarate (author's transl)].

Medizinische Klinik 1977 Oct 14;72;1685-8 — 1977 Oct 14 — 1685-8

Gurtner HP

Pulmonary hypertension, "plexogenic pulmonary arteriopathy" and the appetite depressant drug aminorex: post or propter?

Bulletin europeen de physiopathologie respiratoire 1979 Sep-Oct;15;897-923 — 1979 Sep-Oct — 897-923