The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.b

Pulmonary arterial hypertension

Publications

Karch SB, Defraia B, Messerini L, Mari F, Vaiano F, Bertol E

Aminorex associated with possible idiopathic pulmonary hypertension in a cocaine user.

Forensic science international. 2014;240:e7-10

Karch SB, Mari F, Bartolini V, Bertol E

Aminorex poisoning in cocaine abusers.

International journal of cardiology. 2012;158(3):344-6

Gaine SP, Rubin LJ, Kmetzo JJ, Palevsky HI, Traill TA

Recreational use of aminorex and pulmonary hypertension.

Chest. 2000;118(5):1496-7

Kramer MS, Lane DA

Aminorex, dexfenfluramine, and primary pulmonary hypertension.

Journal of clinical epidemiology. 1998;51(4):361-4

Brenot F, Herve P, Petitpretz P, Parent F, Duroux P, Simonneau G

Primary pulmonary hypertension and fenfluramine use.

British heart journal. 1993;70(6):537-41

Follath F, Burkart F, Schweizer W

Drug-induced pulmonary hypertension?

British medical journal. 1971;1(5743):265-6

Kay JM, Smith P, Heath D

Aminorex and the pulmonary circulation.

Thorax. 1971;26(3):262-70

Berthou JD, Delahaye JP, Brune J, Dorsit G, Delaye J, Roques JC, Gonin A

[Apparently primary pulmonary arterial hypertension in a woman who had taken appetite depressants (Aminorex)].

Revue de tuberculose et de pneumologie. 1972;36(6):944-51

Loogen F, Worth H, Schwan G, Goeckenjan G, Lösse B, Horstkotte D

Long-term follow-up of pulmonary hypertension in patients with and without anorectic drug intake.

Cor et vasa. 1985;27(2-3):111-24

Gurtner HP

[Chronic pulmonary hypertension of vascular etiology, plexogenic pulmonary arteriopathy and the appetite depressant Aminorex: lessons from an epidemic].

Schweizerische medizinische Wochenschrift. 1985;115(24):818-27

Gurtner HP

Aminorex and pulmonary hypertension. A review.

Cor et vasa. 1985;27(2-3):160-71

Widgren S

Pulmonary hypertension related to aminorex intake. Histologic, ultrastructural, and morphometric studies of 37 cases in Switzerland.

Current topics in pathology. Ergebnisse der Pathologie. 1977;64:1-64

Simon H, Felix R

[Reversible pulmonary arterial hypertension after medication of aminorexfumarate (author's transl)].

Medizinische Klinik. 1977;72(41):1685-8

Gurtner HP

Pulmonary hypertension, "plexogenic pulmonary arteriopathy" and the appetite depressant drug aminorex: post or propter?

Bulletin europeen de physiopathologie respiratoire. 1979;15(5):897-923