The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Alveolar hemorrhage (AH), diffuse AH (DAH)
Publications
Brodifacoum poisoning with toxicokinetic data.
Clinical toxicology (Philadelphia, Pa.). 2007;45(5):487-9
Severe coagulopathy as a consequence of smoking crack cocaine laced with rodenticide.
The New England journal of medicine. 2001;345(9):700-1
Fatal brodifacoum rodenticide poisoning: autopsy and toxicologic findings.
Journal of forensic sciences. 1999;44(4):851-5
Superwarfarin poisoning.
Archives of internal medicine. 1998;158(17):1929-32
Brodifacoum intoxication with marijuana smoking.
Archives of pathology & laboratory medicine. 1997;121(1):67-9
Diffuse alveolar hemorrhage secondary to superwarfarin ingestion.
Chest. 1992;102(4):1301-2