Philippe Camus, M.D.
Dijon, France
The superwarfarin brodifacoum is intended to be used as a rodenticide. Poisoning (at times deliberate; oral or inhaled with crack or marijuana fumes/smoke) can occasion severe vit-K depletion and bleeding including alveolar hemorrhage. Longterm vitamin K replacement therapy is necessary, as this class of compounds has a half life of months (see PMID 21740137 and 17215536). Relapse may follow initial improvement. Brodifacoum measurements in blood is indicated
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
