The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Pawar T, Ahuja A, Sontakke T, Wanjari A, Acharya S, Kumar S

Acenocoumarol-Induced Diffuse Alveolar Hemorrhage: A Case Report.

Cureus. 2023;15(4):e37581

Loutfi A, Chibane S, Drighil A, Azzouzi L, Habbal R

[A rare and severe complication related to acenocoumarol therapy: intra-alveolar bleeding].

The Pan African medical journal. 2019;33:160