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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.b

Hematoma of/around central airway wall potentially causing UAO

Publications

Ashraf A, Bannon M, Smith C, Kaushik P, Marak C

Upper airway hematoma: An unusual presentation of acute upper airway obstruction.

Respiratory medicine case reports. 2022;36:101612

Ditkofsky N, Hanna T

Images in Clinical Medicine. Spontaneous Retropharyngeal Hematoma.

The New England journal of medicine. 2016;374(3):e3

Pathak R, Supplee S, Aryal MR, Karmacharya P

Warfarin induced sublingual hematoma: a Ludwig angina mimic.

American journal of otolaryngology. 2015;36(1):84-6

Puri A, Nusrath MA, Harinathan D, Lyall J

Massive sublingual hematoma secondary to anticoagulant therapy complicated by a traumatic denture: a case report.

Journal of medical case reports. 2012;6:105

Vijayan S, Chase A

Images in clinical medicine. Lingual hematoma after thrombolytic therapy.

The New England journal of medicine. 2011;364(7):e13

Mouhaoui M, Khaleq K, Yaqini K, Louardi H

[Sublingual haematoma: an unusual complication of oral anticoagulation therapy: about one case].

Annales francaises d'anesthesie et de reanimation. 2008;27(1):94-6

González-García R, Schoendorff G, Muñoz-Guerra MF, Rodríguez-Campo FJ, Naval-Gías L, Sastre-Pérez J

Upper airway obstruction by sublingual hematoma: a complication of anticoagulation therapy with acenocoumarol.

American journal of otolaryngology. 2006;27(2):129-32

Gupta MK, McClymont LG, El-Hakim H

Case of sublingual hematoma threatening airway obstruction.

Medical science monitor : international medical journal of experimental and clinical research. 2003;9(11):CS95-7

Götte K, Hörmann K

[Dyspnea caused by spontaneous hematoma of the oropharynx and larynx during marcumar therapy].

HNO. 2001;49(3):220-3

Shojania KG

Coumadin-induced lingual hemorrhage mimicking angioedema.

The American journal of medicine. 2000;109(1):77-8

Hefer T, Netzer A, Joachims HZ, Golz A

[Upper airway obstruction--a rare complication after anti-coagulant therapy].

Harefuah. 1993;124(6):336-8, 391

Reussi C, Schiavi JE, Altman R, Yussem EE, Rouvier J

Unusual complications in the course of anticoagulant therapy.

The American journal of medicine. 1969;46(3):460-3

Duong TC, Burtch GD, Shatney CH

Upper-airway obstruction as a complication of oral anticoagulation therapy.

Critical care medicine. 1986;14(9):830-1

Cohen AF, Warman SP

Upper airway obstruction secondary to warfarin-induced sublingual hematoma.

Archives of otolaryngology--head & neck surgery. 1989;115(6):718-20

Di Pasquale G, Salpietro V, Boaron M

[Spontaneous mediastinal hematoma during therapy with oral anticoagulants].

Giornale italiano di cardiologia. 1990;20(10):972-5

Lepore ML

Upper airway obstruction induced by warfarin sodium.

Archives of otolaryngology (Chicago, Ill. : 1960). 1976;102(8):505-6

Rosenbaum L, Thurman P, Krantz SB

Upper airway obstruction as a complication of oral anticoagulation therapy. Report of three cases.

Archives of internal medicine. 1979;139(10):1151-3