The Drug-Induced Respiratory Disease Website and App

Anticoagulants, oral (vitamin K antagonists-VKA)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.n

Hemopericardium - Bloody pericardial effusion

Publications

FELL SC, RUBIN IL, ENSELBERG CD, HURWITT ES

ANTICOAGULANT-INDUCED HEMOPERICARDIUM WITH TAMPONADE: ITS OCCURRENCE IN THE ABSENCE OF MYOCARDIAL INFARCTION OR PERICARDITIS.

The New England journal of medicine. 1965;272:670-4

Lee KS, Marwick T

Hemopericardium and cardiac tamponade associated with warfarin therapy.

Cleveland Clinic journal of medicine. 1993;60(4):336-8

Dacosta A, Comtet C, Tardy B, Guy JM, Page Y, Zéni F, Bertrand JC

[Hemorrhagic tamponade attributed to treatment with antivitamin K].

La Revue de medecine interne. 1992;13(4):323