The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Hemoptysis
Superwarfarins in cannabinoid samples can cause severe bleeding diathesis (See: Kelkar, A.H. et al. An Outbreak of Synthetic Cannabinoid–Associated Coagulopathy in Illinois. N Engl J Med, 2018. 379: 1216-23
Publications
Hemorrhagic Highs from Synthetic Cannabinoids - A New Epidemic.
The New England journal of medicine 2018 09 27;379;1275-1277 — 2018 09 27 — 1275-1277
Superwarfarin poisoning and its management.
BMJ case reports 2014 Oct 13;2014; — 2014 Oct 13