The Drug-Induced Respiratory Disease Website and App

Superwarfarins (vitamin K super antagonist rodenticides)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Olmos V, López CM

Brodifacoum poisoning with toxicokinetic data.

Clinical toxicology (Philadelphia, Pa.). 2007;45(5):487-9

Palmer RB, Alakija P, de Baca JE, Nolte KB

Fatal brodifacoum rodenticide poisoning: autopsy and toxicologic findings.

Journal of forensic sciences. 1999;44(4):851-5

Barnett VT, Bergmann F, Humphrey H, Chediak J

Diffuse alveolar hemorrhage secondary to superwarfarin ingestion.

Chest. 1992;102(4):1301-2