The Drug-Induced Respiratory Disease Website and App

Anticoagulants, oral (vitamin K antagonists-VKA)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.c

Hemoptysis

The possibility of an underlying disease at the origin of hemoptysis (lung cancer, bronchiectais) should not be overlooked

Publications

Abdulmalak C, Cottenet J, Beltramo G, Georges M, Camus P, Bonniaud P, Quantin C

Haemoptysis in adults: a 5-year study using the French nationwide hospital administrative database.

The European respiratory journal 2015 Aug;46;503-11 — 2015 Aug — 503-11

El-Helou N, Al-Hajje A, Ajrouche R, Awada S, Rachidi S, Zein S, Salameh P

Adverse drug events associated with vitamin K antagonists: factors of therapeutic imbalance.

Vascular health and risk management 2013;9;81-8 — 2013 — 81-8