The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Methemoglobinemia
Publications
First case of methemoglobinemia caused by a ClO2-based household product.
Pediatrics international : official journal of the Japan Pediatric Society 2015 Dec;57;1182-3 — 2015 Dec — 1182-3
Severe methemoglobinemia and hemolytic anemia from aniline purchased as 2C-E (4-ethyl-2,5-dimethoxyphenethylamine), a recreational drug, on the Internet - Oregon, 2011.
MMWR. Morbidity and mortality weekly report 2012 Feb 10;61;85-8 — 2012 Feb 10 — 85-8
Methemoglobinemia due to ingestion of N,N-dimethyl-p-toluidine, a component used in the fabrication of artificial fingernails.
Annals of emergency medicine 1988 Oct;17;1098-100 — 1988 Oct — 1098-100
Toxic methaemoglobinaemia. A case of acute nitrobenzene and aniline poisoning treated by exchange transfusion.
Anaesthesia 1977 Mar;32;270-2 — 1977 Mar — 270-2