The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.h

Reactive airway dysfunction syndrome (RADS)

Publications

Saboo K, Gemnani RR, Sharma S, Kumar S, Acharya S

Chemical Pneumonitis and Reactive Airways Dysfunction Syndrome After Fumigation Exposure to Dimethanol and Glutaraldehyde: A Silent Menace Unmasked.

Cureus 2023 Aug;15;e42939 — 2023 Aug — e42939

Fong I, Chew SY, Tan KL

A 27-Year-Old Man With Persistent Breathlessness After an Inhalational Injury.

Chest 2021 Apr;159;e197-e201 — 2021 Apr — e197-e201

Bhardwaj R, Ducatman A, Finkel MS, Petsonk E, Hunt J, Beto RJ

Chronic pulmonary dysfunction following acute inhalation of butyl acrylate.

The West Virginia medical journal 2012 Nov-Dec;108;28-32 — 2012 Nov-Dec — 28-32

Khalid I, Godfrey AM, Ouellette DR

Chemical pneumonitis and subsequent reactive airways dysfunction syndrome after a single exposure to a household product: a case report.

Journal of medical case reports 2009 Nov 09;3;112 — 2009 Nov 09 — 112

Murphy DM, Fairman RP, Lapp NL, Morgan WK

Severe airway disease due to inhalation of fumes from cleansing agents.

Chest 1976 Mar;69;372-6 — 1976 Mar — 372-6