The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.q

Reactive airway dysfunction syndrome (RADS)

Publications

Saboo K, Gemnani RR, Sharma S, Kumar S, Acharya S

Chemical Pneumonitis and Reactive Airways Dysfunction Syndrome After Fumigation Exposure to Dimethanol and Glutaraldehyde: A Silent Menace Unmasked.

Cureus. 2023;15(8):e42939

Fong I, Chew SY, Tan KL

A 27-Year-Old Man With Persistent Breathlessness After an Inhalational Injury.

Chest. 2021;159(4):e197-e201

Bhardwaj R, Ducatman A, Finkel MS, Petsonk E, Hunt J, Beto RJ

Chronic pulmonary dysfunction following acute inhalation of butyl acrylate.

The West Virginia medical journal. 2012;108(6):28-32

Khalid I, Godfrey AM, Ouellette DR

Chemical pneumonitis and subsequent reactive airways dysfunction syndrome after a single exposure to a household product: a case report.

Journal of medical case reports. 2009;3:112

Murphy DM, Fairman RP, Lapp NL, Morgan WK

Severe airway disease due to inhalation of fumes from cleansing agents.

Chest. 1976;69(3):372-6