The Drug-Induced Respiratory Disease Website and App

Anorexigens - Anorectic agents - Appetite suppressants

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVI.b

Pulmonary arterial hypertension

Publications

Ling Y, Johnson MK, Kiely DG, Condliffe R, Elliot CA, Gibbs JS, Howard LS, Pepke-Zaba J, Sheares KK, Corris PA, Fisher AJ, Lordan JL, Gaine S, Coghlan JG, Wort SJ, Gatzoulis MA, Peacock AJ

Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland.

American journal of respiratory and critical care medicine 2012 Oct 15;186;790-6 — 2012 Oct 15 — 790-6

Natali D, Girerd B, Montani D, Soubrier F, Simonneau G, Humbert M, Sitbon O

Pulmonary arterial hypertension in a patient with Cowden syndrome and anorexigen exposure.

Chest 2011 Oct;140;1066-1068 — 2011 Oct — 1066-1068

Souza R, Humbert M, Sztrymf B, Jaïs X, Yaïci A, Le Pavec J, Parent F, Hervé P, Soubrier F, Sitbon O, Simonneau G

Pulmonary arterial hypertension associated with fenfluramine exposure: report of 109 cases.

The European respiratory journal 2008 Feb;31;343-8 — 2008 Feb — 343-8

Goldstein SE, Levy Y, Shoenfeld Y

[Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants].

Harefuah 1998 Dec 01;135;489-92, 568 — 1998 Dec 01 — 489-92, 568

Rich S, Rubin L, Walker AM, Schneeweiss S, Abenhaim L

Anorexigens and pulmonary hypertension in the United States: results from the surveillance of North American pulmonary hypertension.

Chest 2000 Mar;117;870-4 — 2000 Mar — 870-4

Rothman RB, Ayestas MA, Dersch CM, Baumann MH

Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension.

Circulation 1999 Aug 24;100;869-75 — 1999 Aug 24 — 869-75

Louis WJ

Primary pulmonary hypertension and anorectic drugs.

The New England journal of medicine 1999 Feb 11;340;480-2 — 1999 Feb 11 — 480-2

Simonneau G, Fartoukh M, Sitbon O, Humbert M, Jagot JL, Hervé P

Primary pulmonary hypertension associated with the use of fenfluramine derivatives.

Chest 1998 Sep;114;195S-199S — 1998 Sep — 195S-199S

Delcroix M, Kurz X, Walckiers D, Demedts M, Naeije R

High incidence of primary pulmonary hypertension associated with appetite suppressants in Belgium.

The European respiratory journal 1998 Aug;12;271-6 — 1998 Aug — 271-6

Kramer MS, Lane DA

Aminorex, dexfenfluramine, and primary pulmonary hypertension.

Journal of clinical epidemiology 1998 Apr;51;361-4 — 1998 Apr — 361-4

Abenhaim L, Moride Y, Brenot F, Rich S, Benichou J, Kurz X, Higenbottam T, Oakley C, Wouters E, Aubier M, Simonneau G, Bégaud B

Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group.

The New England journal of medicine 1996 Aug 29;335;609-16 — 1996 Aug 29 — 609-16