The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Angioedema (may cause UAO, asphyxia and death)
Publications
Acute airway obstruction due to spontaneous intrathyroid hemorrhage precipitated by anticoagulation therapy.
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2014 Dec;18;825-7 — 2014 Dec — 825-7
Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.
The American journal of geriatric pharmacotherapy 2008 Aug;6;173-7 — 2008 Aug — 173-7
Coumadin-induced lingual hemorrhage mimicking angioedema.
The American journal of medicine 2000 Jul;109;77-8 — 2000 Jul — 77-8