The Drug-Induced Respiratory Disease Website and App

Anticoagulants, oral (vitamin K antagonists-VKA)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VII.g

Hemomediastinum - Mediastinal hematoma

Publications

Abaskaron M, Peterson G, Huang TY

Anterior mediastinal haematoma and left haemothorax on well-controlled oral anticoagulant therapy.

Postgraduate medical journal. 1983;59(688):95-7

Packer JM

Radiologic seminar CXXI: hemomediastinum associated with anticoagulant therapy.

Journal of the Mississippi State Medical Association. 1972;13(10):434-5

Huguenin A, Leborgne P, Pony JC, Lejwi G, Le Carrères D

[Unusual radiologic aspect of a mediastinal hematoma].

La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris. 1968;44(46):2827-30

Di Pasquale G, Salpietro V, Boaron M

[Spontaneous mediastinal hematoma during therapy with oral anticoagulants].

Giornale italiano di cardiologia. 1990;20(10):972-5

Kaplinsky N, Deutsch V, Har Zahav V, Frankl O

[Mediastinal bleeding during anticoagulant simulating dissecting hematoma].

Harefuah. 1978;94(5-6):172-3