The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Publications

Mahmood T, Khasawneh KR, Halloush RA, Khasawneh FA

A 39-year-old male slaughterhouse worker with recurrent fever, cough, and shortness of breath.

Chest. 2013;144(6):1959-1963

Girard M, Cormier Y

Hypersensitivity pneumonitis.

Current opinion in allergy and clinical immunology. 2010;10(2):99-103

Volkman KK, Merrick JG, Zacharisen MC

Yacht-maker's lung: A case of hypersensitivity pneumonitis in yacht manufacturing.

WMJ : official publication of the State Medical Society of Wisconsin. 2006;105(7):47-50

Nakashima K, Takeshita T, Morimoto K

Occupational hypersensitivity pneumonitis due to isocyanates: mechanisms of action and case reports in Japan.

Industrial health. 2001;39(3):269-79