The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

de Prost N, Parrot A, Cuquemelle E, Picard C, Antoine M, Fleury-Feith J, Mayaud C, Boffa JJ, Fartoukh M, Cadranel J

Diffuse alveolar hemorrhage in immunocompetent patients: etiologies and prognosis revisited.

Respiratory medicine. 2012;106(7):1021-32

Schloneger M, Stull A, Singer JI

Inhalant abuse: a case of hemoptysis associated with halogenated hydrocarbons abuse.

Pediatric emergency care. 2009;25(11):754-7

Lazor R, Bigay-Gamé L, Cottin V, Cadranel J, Decaux O, Fellrath JM, Cordier JF, Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires (GERMOP) and the Swiss Group for Interstitial and Orphan Lung Diseases (SIOLD)

Alveolar hemorrhage in anti-basement membrane antibody disease: a series of 28 cases.

Medicine. 2007;86(3):181-193

Załeska M, Zych J, Oniszh K, Rowińska-Zakrzewska E

[Alveolar hemorrhage caused by exposure to pesticides].

Pneumonologia i alergologia polska. 2001;69(3-4):206-10

Kaplan V, Baur X, Czuppon A, Ruegger M, Russi E, Speich R

Pulmonary hemorrhage due to inhalation of vapor containing pyromellitic dianhydride.

Chest. 1993;104(2):644-5