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The Drug-Induced Respiratory Disease Website and App

V.o

V - Pleural and/or pericardial involvement

The 'folded lung' (Blesovsky syndrome)

Last update 17/06/2026

A lesion of the pleura and of the confines of the lung, which consists of a thickened pleura beneath which there is an area of folded, round- or comet-shaped atelectatic lung. Asbestos is a classic and common cause for it. Ergots are the exemplar family of drugs that may cause it. See also under XVIap

Causative drugs

2

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

Ergotamine
V.a
V.c
V.h
V.o
XII.b
XII.k
XVI.an
XVI.ap
Ergots, ergot alkaloids, ergolines
I.b
I.d
I.ak
IV.a
V.a
V.c
V.h
V.m
V.o
VII.d
XI.q
XI.am
XII.a
XII.b
XII.c
XII.g
XV.ao
XVI.an
XVI.ap