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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Antithymocyte globulin (ATG-ALG) - Antithymocyte immunoglobulin (ATI)

3

II.a Pulmonary edema, noncardiogenic (NCPE)

2
Last update : 07/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Pharmacovigilance Analysis of Serious Adverse Events Reported for Biologic Response Modifiers Used as Prophylaxis against Transplant Rejection: a Real-World Postmarketing Experience from the US FDA Adverse Event Reporting System (FAERS).
International journal of organ transplantation medicine 2013;4;62-71 2013
Antithymocyte globulin-induced acute respiratory distress syndrome after renal transplantation: a case report.
Chinese medical journal 2012 May;125;1664-6 2012 May
Anti-thymocyte globulin induced non-cardiogenic pulmonary edema during renal transplantation.
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2011 Oct;15;230-2 2011 Oct
Acute lung injury during antithymocyte globulin therapy for aplastic anemia.
Canadian respiratory journal 2009;16;e3-5 2009
Transient pulmonary infiltrates during treatment with anti-thymocyte globulin.
Respiration; international review of thoracic diseases 1999;66;279-82 1999

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