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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Antithymocyte globulin (ATG-ALG) - Antithymocyte immunoglobulin (ATI)

3

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

2
Last update : 25/02/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

An avoidable cause of thymoglobulin anaphylaxis.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2017;13;13 2017
Successful desensitization of a patient with aplastic anemia to antithymocyte globulin.
Allergy & rhinology (Providence, R.I.) 2015 Jan;6;64-7 2015 Jan
Unexpected death: anaphylactic intraoperative death due to Thymoglobulin carbohydrate excipient.
Forensic science international 2013 May 10;228;e28-32 2013 May 10
Pharmacovigilance Analysis of Serious Adverse Events Reported for Biologic Response Modifiers Used as Prophylaxis against Transplant Rejection: a Real-World Postmarketing Experience from the US FDA Adverse Event Reporting System (FAERS).
International journal of organ transplantation medicine 2013;4;62-71 2013

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