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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Antithymocyte globulin (ATG-ALG) - Antithymocyte immunoglobulin (ATI)

3

II.b ARDS - Acute lung injury

2
Last update : 12/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Acute respiratory distress syndrome mimickers lacking common risk factors of the Berlin definition.
Intensive care medicine 2016 Feb;42;164-72 2016 Feb
Antithymocyte globulin-induced acute respiratory distress syndrome after renal transplantation: a case report.
Chinese medical journal 2012 May;125;1664-6 2012 May
Antithymocyte globulin-induced acute lung injury during transplantation for aplastic anemia.
Journal of pediatric hematology/oncology 2011 Mar;33;150-2 2011 Mar
Acute respiratory distress syndrome after kidney transplantation: epidemiology, risk factors, and outcomes.
Critical care medicine 2003 May;31;1325-30 2003 May
Transient pulmonary infiltrates during treatment with anti-thymocyte globulin.
Respiration; international review of thoracic diseases 1999;66;279-82 1999
ARDS following equine ATG therapy.
Chest 1987 Sep;92;578 1987 Sep
Adult respiratory distress syndrome related to antilymphocyte globulin therapy.
Chest 1987 Apr;91;619-20 1987 Apr

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