Pneumotox » Drug » Propranolol

Propranolol

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For other adverse pulmonary effects of the ß-blocker class as a whole, see under 'ß-blockers'

Last update : 10/03/2020

I.b Pneumonitis (ILD)

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II.a Pulmonary edema, noncardiogenic (NCPE)

1

II.d Pulmonary edema, cardiogenic

1

IV.a Bronchospasm - Wheezing - Asthma

2

IV.f Severe or catastrophic bronchospasm or asthma attack (can be fatal)

2

VIII.e Laryngospasm (a.k.a. laryngismus)

1

IX.i Respiratory arrest - Apnea

1

X.d Lupus - Lupus syndrome (see also Vd)

1

XI.r Death following exposure or poisoning

1

XI.af Refractoriness to epineprine in case of anaphylaxis

1

XII.a Left or biventricular dysfunction/failure

1

XII.n Cardiovascular collapse - Cardiogenic shock - Hypotension

1

XII.p QTc prolongation

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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